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ONGLYZA® (saxagliptin), a prescription medication for adults with type 2 diabetes

Possible side effects of ONGLYZA

Serious side effects can happen to people taking ONGLYZA, including inflammation of the pancreas (pancreatitis), which may be severe and lead to death.

Before taking ONGLYZA, tell your doctor if you have ever had pancreatitis, gallstones, a history of alcoholism, or high triglyceride levels.

Stop taking ONGLYZA and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.


Serious allergic reactions can occur as possible side effects of ONGLYZA and may include:

  • Swelling of the face, lips, or throat
  • Difficulty swallowing or breathing
  • Swelling of the skin
  • Hives, rash, itching, flaking, or peeling

If you have these symptoms, stop taking ONGLYZA, and contact your doctor right away.


Common side effects of ONGLYZA include:

  • Upper respiratory tract infection
  • Urinary tract infection
  • Headache


Low blood sugar (hypoglycemia)

Low blood sugar (hypoglycemia) may become worse in people who already take another medication to treat diabetes, such as a sulfonylurea or insulin. Tell your doctor if you take other diabetes medicines. If you have symptoms of low blood sugar, you should check your blood sugar and treat if low; then call your doctor. Symptoms of low blood sugar include shaking, hunger, sweating, headache, rapid heartbeat, change in mood, or change in vision.


Swelling or fluid retention

Swelling or fluid retention in your hands, feet, or ankles (peripheral edema) may become worse in people who also take a thiazolidinedione (TZD), such as pioglitazone or rosiglitazone, to treat high blood sugar. If you have symptoms of peripheral edema, such as swelling of hands, feet, or ankles, call your doctor. If you do not know whether you are already on this type of medication, ask your doctor.

These are not all of the possible side effects of ONGLYZA. Tell your doctor if you have any side effects of ONGLYZA that bother you or that do not go away. For more information, ask your doctor.

Learn more about possible side effects of ONGLYZA

View the Medication Guide »


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