Talking With Your Doctor About Onglyza
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Before You Start Onglyza

If you’re starting on Onglyza (saxagliptin), tell your doctor about all of your medical conditions, including if you:

  • Have had inflammation of the pancreas (pancreatitis), gallstones, a history of alcoholism, or high blood triglyceride levels. It is not known if you have a higher chance of getting pancreatitis while taking Onglyza.
  • Have had a serious allergic (hypersensitivity) reaction to Onglyza or any other similar medications (DPP-4 inhibitors) which are used to control high blood sugar.
  • Have type 1 diabetes. Onglyza should not be used to treat people with type 1 diabetes.
  • Have a history or risk for diabetic ketoacidosis (increased ketones in the blood or urine). Onglyza should not be used for the treatment of diabetic ketoacidosis.
  • Have kidney problems.
  • Are pregnant or plan to become pregnant. It is not known if Onglyza will harm your unborn baby. If you are pregnant, talk with your doctor about the best way to control your blood sugar while you are pregnant.
  • Are breast-feeding or plan to breast-feed. Onglyza may be passed in your milk to your baby. Talk with your doctor about the best way to feed your baby while you take Onglyza.

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

Onglyza may affect the way other medicines work, and other medicines may affect how Onglyza works. Contact your doctor if you will be starting or stopping certain other types of medications, such as antibiotics, or medicines that treat fungus or HIV/AIDS, because your dose of Onglyza might need to be changed.

Need help talking with your doctor about type 2 diabetes? The Type 2 Diabetes Doctor Discussion Guide can help.


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Have Questions?
Learn more about Onglyza in the FAQ section.

IMPORTANT SAFETY INFORMATION
for ONGLYZA (saxagliptin)

Do not take ONGLYZA (saxagliptin) if you are allergic to any of its ingredients. Serious allergic reactions can occur with ONGLYZA and may include swelling of the face, lips or throat, difficulty swallowing or breathing, swelling of the skin, hives, rash, itching, flaking, or peeling. If you have these symptoms, stop taking ONGLYZA and contact your doctor right away.

Serious side effects can happen to people taking ONGLYZA, including inflammation of the pancreas (pancreatitis) which may be severe and lead to death. Before taking ONGLYZA, tell your doctor if you ever had pancreatitis, gallstones, history of alcoholism, or high triglyceride levels. Stop taking ONGLYZA and contact your doctor right away if you have pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen through to your back. The pain may happen with or without vomiting. These may be symptoms of pancreatitis.

WHAT IS ONGLYZA?

ONGLYZA (saxagliptin) is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes.

ONGLYZA should not be used to treat people with type 1 diabetes or diabetic ketoacidosis (increased ketones in the blood or urine).

If you have had inflammation of the pancreas (pancreatitis), it is not known if you have a higher chance of getting pancreatitis while taking ONGLYZA.

When ONGLYZA is used with certain other diabetes medicines to treat high blood sugar, such as a sulfonylurea or insulin, the risk of low blood sugar (hypoglycemia) is higher. Symptoms of low blood sugar include shaking, hunger, sweating, headache, rapid heartbeat, change in mood, and change in vision. Follow your doctor’s instructions for treating low blood sugar.

When ONGLYZA is used with a thiazolidinedione (TZD), such as pioglitazone or rosiglitazone, to treat high blood sugar, peripheral edema (fluid retention) may become worse. If you have symptoms of peripheral edema, such as swelling of hands, feet, or ankles, call your doctor.

The most common side effects with ONGLYZA include upper respiratory tract infection, urinary tract infection, and headache.

Your doctor should test your blood to measure how well your kidneys are working before and during treatment with ONGLYZA. You may need a lower dose if your kidneys are not working well.

Tell your doctor if you start or stop taking other medications, including antibiotics, antifungals or HIV/AIDS medications, as your doctor may need to change your dose of ONGLYZA.

Tell your doctor if you are pregnant, breast-feeding, or plan to become pregnant or breast-feed.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please click here for Medication Guide, and click here for US Full Prescribing Information for ONGLYZA (saxagliptin).

This product information is intended for US customers only.

©2013 AstraZeneca Pharmaceuticals LP.

ONGLYZA is a registered trademark of the AstraZeneca group of companies.

1806603‐3013604 Last updated 06/13

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