Extra Control With Onglyza™

Talk to your doctor about how morning blood sugar (FPG), after-meal blood sugar (PPG), or both, can affect your A1C level.

Your doctor may recommend that you measure your blood sugar in the morning and after meals using a meter. The reading you take in the morning before you eat is called your FPG or fasting number. This reading will help you and your doctor better understand how well your blood sugar is being controlled when you haven't eaten in a while.

Another important reading to take is your PPG or after-meal number. Everyone's blood sugar spikes after they eat. But if you have type 2 diabetes, it may spike too high, a signal that you need more control.

Morning blood sugar (FPG), after-meal blood sugar (PPG), or both, can affect your A1C level.

A1C reflects a 3-month average of your blood sugar. This reading is done at your doctor's office or at a lab. Your doctor will use the results from your A1C test as well as your before-meal and after-meal readings to help manage your type 2 diabetes. If your doctor thinks your after-meal or morning blood sugar or your A1C levels are too high, your doctor may need to adjust your current treatment or add another medication to your current oral diabetes medicine.

In clinical studies, Onglyza™ lowered A1C, morning blood sugar (FPG), and after-meal blood sugar (PPG) when added to one of several common oral diabetes medicines. The most common side effects with Onglyza include upper respiratory tract infection, urinary tract infection, and headache.

The American Diabetes Association recommends an A1C of under 7

Make sure you talk to your doctor about your goals for your morning blood sugar (FPG), your after-meal blood sugar (PPG) and your A1C, and how you can best achieve them.

Onglyza may help you achieve better blood sugar control

Onglyza may help lower A1C, morning blood sugar (FPG), and after-meal blood sugar (PPG) when added to one of several common oral diabetes medicines, such as metformin, a thiazolidinedione (TZD), or a sulfonylurea.

When ONGLYZA is used with certain other diabetes medicines to treat high blood sugar, such as a sulfonylurea, low blood sugar (hypoglycemia) may occur. Follow your healthcare provider's instructions for treating low blood sugar. Symptoms of low blood sugar include shaking, hunger, sweating, headache, rapid heartbeat, change in mood, and change in vision.

When ONGLYZA is used with a thiazolidinedione, such as pioglitazone or rosiglitazone, to treat high blood sugar, peripheral edema (fluid retention) may become worse. If you have symptoms of peripheral edema, such as swelling of hands, feet, or ankles, call your healthcare provider.

See Why Onglyza to learn more about how Onglyza may give you extra help to treat high blood sugar.

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IMPORTANT INFORMATION ABOUT ONGLYZA™ (saxagliptin)

Approved Uses

ONGLYZA™ (saxagliptin) is a prescription medicine used along with diet and exercise to lower blood sugar in adults with type 2 diabetes mellitus.

ONGLYZA has not been studied with insulin.

ONGLYZA should not be used to treat people with type 1 diabetes or to treat diabetic ketoacidosis (dangerously high levels of certain acids, known as ketones, in the blood or urine).

Important Safety Information

When ONGLYZA is used with certain other diabetes medicines to treat high blood sugar, such as a sulfonylurea, low blood sugar (hypoglycemia) may occur. Symptoms of low blood sugar include shaking, hunger, sweating, headache, rapid heartbeat, change in mood, and change in vision. Follow your healthcare provider's instructions for treating low blood sugar.

If you have allergic (hypersensitivity) reactions, such as rash, hives, and swelling of the face, lips, and throat, stop taking ONGLYZA and call your healthcare provider right away.

When ONGLYZA is used with a thiazolidinedione (TZD), such as pioglitazone or rosiglitazone, to treat high blood sugar, peripheral edema (fluid retention) may become worse. If you have symptoms of peripheral edema, such as swelling of hands, feet, or ankles, call your healthcare provider.

The most common side effects with ONGLYZA include upper respiratory tract infection, urinary tract infection, and headache.

Your healthcare provider should test your blood to measure how well your kidneys work. You may need a lower dose of ONGLYZA if your kidneys are not working well.

Tell your healthcare provider if you start or stop taking other medications, including antibiotics, antifungals or HIV/AIDS medications, as your healthcare provider may need to change your dose of ONGLYZA.

Tell your healthcare provider if you are pregnant or breast-feeding, or plan to become pregnant or breast-feed.

Please see US Full Prescribing Information, including Patient Information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Bristol-Myers Squibb and AstraZeneca do not review the information on this Web site and/or database for content, accuracy, or completeness. Use of and access to this information is subject to the terms, limitations, and conditions set by the Web site and/or database producer.

Bristol-Myers Squibb and AstraZeneca make no representation as to the accuracy or any other aspect of the information contained on such Web site and/or database, nor does Bristol-Myers Squibb or AstraZeneca necessarily endorse such Web site and/or database.

Bristol-Myers Squibb and AstraZeneca do not review the information on this Web site and/or database for content, accuracy, or completeness. Use of and access to this information is subject to the terms, limitations, and conditions set by the Web site and/or database producer.

Bristol-Myers Squibb and AstraZeneca make no representation as to the accuracy or any other aspect of the information contained on such Web site and/or database, nor does Bristol-Myers Squibb or AstraZeneca necessarily endorse such Web site and/or database.